![]() Reserved for life-threatening bleeding, eg.Monoclonal antibody fragment which binds dabigatran with 350 times more affinity than thrombin, neutralising its activity.Reserved for situations when the prothrombinex is not readily available, or where volume resuscitation is desirable, or where acute haemorrhage has caused the consumption of all clotting factors (as a part of a massive transfusion).Replaces numerous clotting factors, among them factors II, VII, IX, and X,.Indicated where immediate reversal is required (for example, bleeding into a vital organ, eg.Replaces missing factors II, VII, IX, and X, bypassing their blocked synthesis.Indicated as sole agent for stable patients, or as an adjunct where the patient has lifethreatening bleeding.Dose ranges from 1mg orally (if stable) up to 10mg IV (if bleeding).Replaces reduced vitamin K, bypassing the inhibited vitamin K epoxide reductase complex, and permitting the synthesis of active factors II, VII, IX, and X.Dose is 1mg protamine for each 1mg of enoxaparin. ![]()
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